Tuesday, December 3, 2019

Vitamin D deficiency can cause heart disease

Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). It plays a major role in bones and calcium metabolism.

Recent research has linked inadequate vitamin D status to non-skeletal major chronic diseases, especially cardiovascular diseases. Existing data from laboratory studies, epidemiologic and experimental research and prevention trials, suggest that vitamin D reduces the risk of cardiovascular disease.

Through increased renin and angiotensin II synthesis, vitamin D deficiency can increase the production of reactive oxygen species and G protein RhoA, resulting in inhibition of the pathways necessary for intracellular glucose transporter and thus the development of insulin resistance and metabolic syndrome. In addition, direct effects of vitamin D upon smooth muscle calcification and proliferation could contribute to their effects on cardiovascular health.

Studies have also demonstrated a link between vitamin D deficiency and progression of atherothrombosis and vascular calcification. Vitamin D has been found to regulate macrophage maturation and infiltration into the vasculature, subsequently regulating the expression of pro-inflammatory cytokines and adhesion molecules, which are critical components in the progression of atherosclerosis. These findings are also in line with observations that vitamin-D deficient patients have increased plaque instability and incidence of myocardial infarction.
Vitamin D deficiency can cause heart disease

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