Hypervitaminosis
Acute hypervitaminosis A results from ingestion of very large amounts of the vitamin during a relatively short period of time.
The symptoms, which resolve after supplementation is stopped, include irritability, headache, vomiting, bone pain, weakness, blurred vision, and peeling of the skin.
Chronic hypervitaminosis A can result from high intakes of vitamin A over long period of time and/or in connection with liver or kidney disease.
Some of the signs of chronic hypervitaminosis A are dry skin, hair loss, weakness, headache, bone thickening, enlarged, liver and spleen, anemia, abnormal menstrual periods, stiffness and joint pain; most of these symptoms are reversible, but bone changes and liver damage may be permanent.
Vitamin A in very large doses is known to be teratogenic in many animals. Excessive intake of vitamin A has also been associated with human congenital abnormalities in some cases reports although a causal relationship has not been established.
High intakes should be avoided by pregnant women.
Levels of vitamin A intake associated with hypervitaminosis A varies according to the health and size of the person.
As little as 12,000 IU/day, given to small children for an extended period, has reportedly led to toxicity symptoms.
Hypervitaminosis A may result from acute ingestion of about 500,000 IU of vitamin A by an adult, or from a chronic daily intake of about 100,000 IU.
Hypervitaminosis
Vitamins are defined as a group of complex organic compounds present in minute amounts in natural foodstuff that are essential to normal metabolism and lack of which in the diet causes deficiency diseases. Vitamins are required in trace amounts (micrograms to milligrams per day) in the diet for health, growth and reproduction.
Tuesday, November 17, 2009
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